Our mRNA technology can realize the integration of nucleic acid+delivery, and the mRNA platform established by Makikon Biology has non-replication mRNA technology: the mRNA sequence produced by independent design and construction is directly used as a bioreactor by individual cells to express antigen protein, induce balanced humoral immunity and cellular immunity, and be used to develop preventive infectious disease vaccine; With self-replicating mRNA technology: self-replicating the mRNA through the self-replicating enzyme system of the early translation product of mRNA, and the independently developed non-LNP NLCv1 and NLCv2 liposome system is used for the delivery of self-replicating mRNA, and the innovative exploration of preventive infectious disease vaccine and tumor therapeutic vaccine.